Adenomatoid odontogenictumourjawelinicalstatistics. Calcifying epithelial odontogenic tumors ceots and calcifying odontogenic cysts cocs are rare, benign odontogenic tumors. Adenomatoid odontogenic tumors represent 3 to 7% of all odontogenic tumors. The tumor which today is called adenomatoid odontogenic tumor aot was probably first described by dreibladt 1907, quoted in thoma 1970, who called the tumor pseudoadenoma adamantinum, and then by harbitz 1915, who called it adamantine cystadenoma gorlin and.
Dentigerous cyst associated with adenomatoid odontogenic. Notch signaling affects oral neoplasm cell differentiation. Adenomatoid odontogenic tumor aot is a benign neoplasm of odontogenic epithelium. In the whoiarc classification of head and neck pathology, this clinical entity had been known for years as the odontogenic keratocyst. Adenomatoid odontogenic tumor aot is a relatively rare neoplasm. Multiple adenomatoid odontogenic tumors in a patient with. Adenomatoid odontogenic tumors aot are exceptionally rare and benign, originating in the odontogenic epithelium and accounting for 2. Expression of ck14 and vimentin in adenomatoid odontogenic tumor and dentigerous cyst.
Expression of ck14 and vimentin in adenomatoid odontogenic. Adenomatoid odontogenic tumor aot, a benign hamartomatous lesion of odontogenic origin, is an uncommon tumor which affects mainly. Adenomatoid odontogenic tumor is a successional tooth. Anna saito, akira taguchi, hiromasa hasegawa and hideaki kagami, a case of adenomatoid odontogenic tumor with unusual presentation extending from gingiva to periodontal space, journal of oral and maxillofacial surgery, medicine, and pathology, 10. Peripheral adenomatoid odontogenic tumor in a cloak of an. In the past, this tumor has been referred to as adenoameloblastoma or ameloblastic adenomatoid tumor. They are also seen more frequently in females, most frequently in the second decade of life. Adenomatoid odontogenic tumor aot, a benign hamartomatous lesion of odontogenic origin, is an uncommon tumor which affects mainly females in the. Adenomatoid odontogenic tumor aot belongs to a group of rare benign odontogenic lesions and constitutes approximately 37% of all odontogenic tumors 7 8 9. Pdf dentigerous cyst or adenomatoid odontogenic tumor. The adenomatoid odontogenic tumor is an odontogenic tumor arising from the enamel organ or dental lamina.
Pdf here we report a case of adenomatoid odontogenic tumor aot in the maxilla in a young girl aged 14 years and its surgical management. Adenomatoid odontogenic tumor aot is an uncommon tumor of odontogenic origin. Only about 750 cases have been reported in scientific literature. Adenomatoid odontogenic tumor aot is an uncom mon benign neoplasm of odontogenic epithelial origin accounting for less than 3% of all. Adenomatoid odontogenic tumor associated with dentigerous cyst of the maxillary antrum. This paper reported a case of aot, in a 16yearold female, associated with an impacted maxillary left lateral incisor. Treatment for large adenomatoid odontogenic tumors.
Adenomatoid odontogenic tumor associated with an impacted. Adenomatoid odontogenic tumor aot is a benign lesion, rare, slow growing and progressive. Adenomatoid odontogenic tumor constitutes an uncommon benign odontogenic tumor which is wellknown as twothirds tumor twothirds of adenomatoid tumors occur in the maxilla, twothirds occur in young females, twothirds of the cases are associated with unerupted teeth and twothirds of the affected teeth are canines. This lesion is most commonly associated with an impacted maxillary canine. Ameloblastomas and adenomatoid odontogenic tumors aots are. Adenomatoid odontogenic tumour aot adenomatoid odontogenic tumour aot consists of spindleshaped cells forming nodules that may contain droplets of eosinophilic material and columnar cells lining spaces that are either empty or contain eosinophilic material. Clinical statistics of the adenomatoid odontogenic tumour. Here, we report the first case of multiple adenomatoid odontogenic tumor observed in a patient with ss. It is a benign hamartomatous, noninvasive lesion with slow but progressive growth. We report two cases of an exceptional combination of these tumors with either an ameloblastic fibroodontoma or an odontoma. Adenomatoid odontogenic tumor aot is a rare odontogenic tumor which is often misdiagnosed as odontogenic cyst.
A 35year retrospective study of 250 cases in an indian maharashtra teaching institute. Odontogenic keratocysts make up around 19% of jaw cysts. The authors present two examples of a combined epithelial odontogenic tumor which contained areas diagnostic for both adenomatoid odontogenic tumor and calcifying epithelial odontogenic tumor. Odontogenic tumours an update diagnostic histopathology. The female population has the highest incidence of reported cases, with a prevalent age range of 10 to 30 years, mainly the second decade of life. Adenomatoid odontogenic tumour displacing multiple teeth.
Int j oral maxillofac surg decade of life, the first in a girl and the figure 1. Full text pdf 2618k abstracts references50 citedby17 the present biological profile of the adenomatoid odontogenic tumour represents an updating of the data published by the authors from 1990 to 1996. Hybrid odontogenic tumor, hybrid odontogenic cyst, hybrid odontogenic neoplasm, dentigerous cyst, calcifying odontogenic cyst, adenomatoid odontogenic cyst v w gruza a, choi j, chen c, et al. Two thirds of cases are located in the anterior maxilla, and one third are present in the anterior mandible. It is well known for its unique histopathologic features, predilection for young individuals, and innocuous behavior.
This epithelial tumor has an inductive effect on the odontogenic ectomesenchyme with dentinoid frequently being produced. Pdf background to present 14 cases of adenomatoid odontogenic tumor aot, highlighting. The adenomatoid odontogenic tumor is completely benign. Adenomatoid odontogenic tumor aot is a distinct odontogenic tumor that is exclusively odontogenic epithelium in origin which accounts for about 37% of all odontogenic tumors. Benign tumors include benign epithelial odontogenic tumors, benign mixed epithelial and. Adenomatoid odontogenic tumour aot is a benign noninvasive odontogenic tumour, having mostly a slow and sustained growth pattern. It is predominantly found in young and female patients, located more often in the. When grown, one can palpate a hard and large lesion. Odontogenic tumors are both benign and malignant and have been classified accordingly by who in 1992 which was further divided into sub divisions by white dk in 2004. The adenomatoid odontogenic tumour aot has been known by a number of descriptive names adenoameloblastoma, ameloblastic adenomatoid tumour, glandular ameloblastoma, and adenomatoid. Adenomatoid odontogenic tumor aot, a benign hamartomatous lesion of odontogenic origin, is an uncommon tumor which affects mainly females in the second decade. Adenomatoid odontogenic tumors are rare and differ from most other dentition related lesions in that they more frequently occur in the maxilla epidemiology. Several tumors exist, which only appear to occur in the jaws. It is a relatively uncommon neoplasm that accounts for about 3% of all odontogenic tumors being more common in the maxilla and in females, more often.
Case report cystic adenomatoid odontogenic tumor sonalgrover, 1 ahmedmujibbangalorerahim, 2 nithinkavasseryparakkat, 3 shekharkapoor, 4 kumudmittal, 5 bhushansharma, 1 andanilbangaloreshivappa 6 department of oral pathology and microbiology, christian dental college, cmc, ludhiana, punjab, india. Aot is an uncommon lesion of odontogenic origin, which affects young individuals, with a female predilection and mostly occurring in the second decade. Ameloblastoma and adenomatoid odontogenic tumor ncbi. An unusual presentation of adenomatoid odontogenic tumor. Ameloblastoma, adenomatoid odontogenic tumor, jaws, odontogenic tumors, odontoma how to cite this article. Adenomatoid odontogenic tumor pdf adenomatoid odontogenic tumor aot, a benign hamartomatous lesion of odontogenic origin, is an uncommon tumor which affects mainly. Adenomatoid odontogenic tumor aot is a benign lesion from the dental lamina or its remains. This paper reports a case of a 12yearold boy with a bony consistence tumefaction involving the area from teeth 12 to 17.
The histologic presentation, histogenesis, and suggested treatment are discussed. Adenomatoid odontogenic tumor case report case report vol. Although they do not normally contain odontogenic tissue, they are probably odontogenic because of their site of origin. Adenomatoid odontogenic tumor aot is a wellrecognised slow growing benign tumor derived from complex system of dental lamina or its remnants. Adenomatoid odontogenic tumor is a benign epithelial odontogenic tumor. The adenomatoid odontogenic tumor aot is usually an asymptomatic slow growth lesion. It affects young patients and is usually associated with an impacted tooth, generally the canine. Aggressive behavior and recurrence after enucleation is exceedingly rare thus supporting its questionable hamarmatous nature 3,4,6,9. Its occurrence represents 3% of all odontogenic tumors. Adenomatoid odontogenic tumour is a benign hamartomatous, noninvasive lesion with slow but progressive growth. Adenomatoid odontogenic tumor aot formerly called an adenoameloblastoma, a somewhat deceptive term that should be discarded, the aot represents about 37 % of all odontogenic tumors. Adenomatoid odontogenic tumors pdf posted on january 29, 2020 by admin adenomatoid odontogenic tumor aot, a benign hamartomatous lesion of odontogenic origin, is an uncommon tumor which affects mainly.
Several new facets of this tumour appear from the approximately 250 cases having. Adenomatoid odontogenic tumor aot is a slowgrowing. Ahire ms, tupkari jv, chettiankandy tj, thakur a, agrawal rr. G12v mutations were reported in a small cohort of aot. Two thirds of the cases are associated with an impacted tooth usually being the canine. Oral manifestations related to ss mainly include dental defects, papillary lesions in the oral mucosa, giant cell lesions of the jaws, and odontogenic tumors. In some cases these small calcifications combine to form large.
Since its first description by ghosh in 1934, more than 160verifiable caseshave been reported worldwide115. Benign odontogenic tumors are divided into three types based on the presence absense of odontogenic epithelium or ectomesenchyme. This lesion is categorised into three variants of which the more common variant is follicular type which is often mistaken for dentigerous cyst. It has two clinicopathologic variants, namely intraosseous follicular and. Enucleation of a rare hybrid odontogenic lesion in the. This is an open access article distributed under the terms of the creative commons attributionnoncommercialsharealike 3. Benign and slowgrowing, it is believed to originate from the remnants of the dental lamina or the enamel organ 1,46. A well circumscribed lesion derived from odontogenic epithelium that usually occurs around the crowns of unerupted anterior teeth of young patients and consists of epithelium in swirls and ductal patterns interspersed with spherical calcifications. It is common for the tumor to cause shifting of neighboring teeth because tumor expansion is more common than teeth root resorption. Introduction the adenomatoid odontogenic tumour aot is a benign, hamartomatous lesion of odontogenic epithelial origin1. Even though there is evidence that tumor cells originate from the epithelium of the tooths enamel, it has been suggested that. Adenomatoid odontogenic tumor aot is an uncommon benign odontogenic lesion that affects young patients associated with an impacted tooth, usually canine. Pdf adenomatoid odontogenic tumor, an uncommon tumor.
Adenomatoid odontogenic tumor e16 introduction adenomatoid odontogenic tumor aot is an uncommon benign neoplasm of odontogenic epithelial origin accounting for less than 3% of all odontogenic tumors. Adenomatoid odontogenic tumor is an unusual benign neoplasm which shares clinical and radiographic characteristics with odontogenic cystic lesions denoting a distinct behavior. Pdf adenomatoid odontogenic tumours with a diameter of more than 4 cm are uncommon. Adenomatoid odontogenic tumor is a hamartomous benign neoplasia of odontogenic origin.
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